PRESS AND PUBLICATIONS

All the publications below acknowledge ENGAGE funding.

2010

Teslovichet al.. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 August; 466(7307):707-13

Voight et al.. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42: 579–589

Wang et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jun 9. [Epub ahead of print]

Naukkarinen et al. Use of genome-wide expression studies to mine the "gray zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet. 2010 Jun 3;6(6):e1000976. (ENGAGE led publication)

Blankenberg et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation. 2010 Jun 8;121(22):2388-97. Epub 2010 May 24.

Widén et al. Distinct variants at LIN28B influence growth in height from birth to adulthood. Am J Hum Genet. 2010 May 14;86(5):773-82. Epub 2010 Apr 15.

Walters et al. A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome 16p11. Nature 2010;463:671-675. PMID: 20130649

Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior and the risk of lung cancer. Nat Genet 2010;42:448-453.

Pillas et al. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics 2010;6:e1000856.

Freathy et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010 May;42(5):430-5. Epub 2010 Apr 6.

Chambers et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):373-5. Epub 2010 Apr 11.

Tassé AM, Budin-Ljøsne I, Knoppers BM, Harris JR. Retrospective access to data: the ENGAGE consent experience. Eur J Hum Genet. 2010 Mar 24. [Epub ahead of print]

Ingelsson et al. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. Diabetes (2010) 59; 1266-75 Feb 25. [Epub ahead of print]

Milani et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood. 2010 Feb 11;115(6):1214-25. Epub 2009 Nov 25.

Saxena et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010 Feb;42(2):142-8. Epub 2010 Jan 17.

Codd et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010 Mar;42(3):197-9. Epub 2010 Feb 7.

Dupuis et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Jan 17.

Illig et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41. Epub 2009 Dec 27.

Repapi et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010 Jan;42(1):36-44. Epub 2009 Dec 13. PubMed PMID: 20010834.

2009

Richards et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.

Menezes et al. Integrated analysis of DNA copy number and gene expression microarray data using gene sets. BMC Bioinformatics 10:203 (2009)

Eleftherohorinou et al. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One. Nov 30;4(11) (2009).

Soranzo et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics 41(11), 1182- 90 (2009). Published online: 11 October 2009

Chambers et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics 41(11), 1161-2 (2009). Published online: 11 October 2009

Krestyaninova et al. A System for Information Management in BioMedical Studies--SIMBioMS. Bioinformatics. 2009 Oct 15;25(20):2768-9. Epub 2009 Jul 24.

Jonsson et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Oct;58(10):2409-13. Epub 2009 Jul 7.

Kolz et al. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.

Grisoni et al. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 2009 May 27;10:44.

Saarela O, Kulathinal S, Karvanen J. Joint analysis of prevalence and incidence data using conditional likelihood. Biostatistics. 2009 Jul;10(3):575-87. Epub 2009 May 20.

Newton-Cheh et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41, 666 - 676 (2009). 2009 May 10. [Epub ahead of print]

Iris M. Heid et al., Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Plos Gen 2009;5:e1000694

Karvanen et al. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009;33:237-246.

Mari Nelis, Tõnu Esko et al. Genetic Structure of Europeans: a view from the North-East. PLoS ONE 4(5): e5472

Sovio U et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009 Mar;5(3):e1000409. Epub 2009 Mar 6.

Bartha Maria Knoppers. Genomics and policymaking: from static models to complex systems? Human Genetics 2009 May;125(4):375-9. Epub 2009 Feb 28

Pulizzi et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia. 2009 May;52(5):825-9. Epub 2009 Feb 19.

Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009 May;29(5):774-80. Epub 2009 Jan 22.

Erdmann et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics. 2009 Mar;41(3):280-2. Epub 2009 Feb 8.

Valeriya et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature Genetics 41, 82 - 88 (2009) Published online: 7 December 2008

Inga Prokopenko et al. Variants in MTNR1B fasting glucose levels. Nature Genetics 41, 77 - 81 (2009) Published online: 7 December 2008 | doi:10.1038/ng.290 (ENGAGE led publication)

Aulchenko, Ripatti et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics 41, 47 - 55 (2009) Published online: 7 December 2008 (ENGAGE led publication)

Sabatti et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics 41, 35 - 46 (2009). Published online: 7 December 2008

Willer et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41:25-34 (2009)

Cristen J Willer et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41, 25 - 34 (2009). Published online: 14 December 2008

Gudmar Thorleifsson et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 41, 18 - 24 (2009). Published online: 14 December 2008

2008

Saarela O et al. Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives. Stat Med. 2008 Dec 10;27(28):5991-6008.

Grisoni M-L et al. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. European Journal of Human Genetics. 2008 Dec;16(12):1512-20. Epub 2008 Jul 16.