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PRESS AND PUBLICATIONS

All the publications below acknowledge ENGAGE funding
European Community's Seventh Framework Programme (FP7/2007-2013); Grant Agreement HEALTH-F4-2007- 201413

ENGAGE Executive Summary Period 1-4 (01.01.2008-31.12.2012)

ENGAGE Final Publishabe Summary Report (2008-2012)

 

ENGAGE on Youtube

'From Genetic Discovery to Future Health', produced in collaboration with Fast Facts

'European Netwok for Genetic and Genomic Epidemiology-ENGAGE video

 

2013

Ahlqvist E et al., A link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes 2013 January 24 (Epud ahead of print) doi: 10.2337/db12-0976

Albrechtsen A et al, Exome sequencing-driven discovery of variants associated with common metabolic phenotypes. Diabetologia 56;298-310,2013. doi: 10.1007/s00125-012-2756-1

Anttila V, Winsvold BS et al, Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013 Jun 23. doi: 10.1038/ng.2676. [Epub ahead of print] .

Berndt SI et al, Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 May;45(5):501-12. doi: 10.1038/ng.2606. Epub 2013 Apr 7.

Budin-Ljøsne I et al, Data sharing in large research consortia: experiences and recommendations from ENGAGE. Eur J Hum Genet. 2013 [Epub ahead of print 19 June 2013]; doi: 10.1038/ejhg.2013.131

Budin-Ljøsne I, Soye KJ, Tassé AM, Knoppers BM, Harris JR. Genotype-driven recruitment: a strategy whose time has come? BMC Med Genomics. 2013 May 23;6:19. doi: 10.1186/1755-8794-6-19.

Broer L et al. Meta-analysis of telomere length in 19_713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet. 2013 Jan 16. doi: 10.1038/ejhg.2012.303. [Epub ahead of print] doi: 10.1038/ejhg.2012.303

Codd V, Nelson C, Albrecht E et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013 Apr;45(4):422-7. doi: 10.1038/ng.2528 (ENGAGE Flagship Project Paper)

Fatemifar G et al, Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet. 2013 Jun 5. [Epub ahead of print] doi: 10.1093/hmg/ddt231

Fall T et al., Pedersen NL, McCarthy MI, Ingelsson E, Prokopenko I, for the European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Med 10(6): e1001474. doi:10.1371/journal.pmed.1001474 (ENGAGE Flagship Project Paper).

Ganna A, Rivadeneira F, Hofman A, Uitterlinden AG, Magnusson PKE, Pedersen NL, Ingelsson E, Tiemeier H. Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality? Hum Genet. 2013 Jan 25. [Epub]

Gao, H et al., Evidence of a Causal Relationship between Adiponectin Levels and Insulin Sensitivity: A Mendelian Randomization Study. Diabetes. 2013 Apr;62(4):1338-44. doi: 10.2337/db12-0935.

Horikoshi M et al, New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013 Jan;45(1):76-82. doi: 10.1038/ng.2477. Epub 2012 Dec 2.

Menzel S et al., HbA(2) levels in normal adults are influenced by two distinct genetic mechanisms. Br J Haematol 2013 Jan;160(1):101-5. PMID: 23043469.

Randall JC et al, Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genet. 2013 Jun;9(6):e1003500. doi: 10.1371/journal.pgen.1003500. Epub 2013 Jun 6.

Rietveld CA et al, GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.

Rung J, Brazma A. Reuse of public genome-wide gene expression data. Nat Rev Genet. 2013 Feb;14(2):89-99 (Epub 2012 Dec 27.)

Rustici et al., ArrayExpress update--trends in database growth and links to data analysis tools. Nucleic Acids Res. 2013 Jan;41(Database issue):D987-90.. Epub 2012 Nov 27.

Verhoeven VJ et al, Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet. 2013 Mar;45(3):314-8. doi: 10.1038/ng.2554. Epub 2013 Feb 10.

Vimaleswaran KS et al., Genetic association analysis of vitamin D pathway with obesity traits. Int J Obes (Lond). 2013 Feb 5. doi: 10.1038/ijo.2013.6. [Epub ahead of print]

Zhernakova DV et al, DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and noncoding transcripts. PLoS Genet 9(6): e1003594. doi:10.1371/journal.pgen.1003594 (ENGAGE Flagship Project Paper)

 

2012

Ali Khan A, Rodriguez A, Sebert S, Kaakinen M, Cauchi S, et al. (2012) The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size. PLoS ONE 7(6): e38216. doi:10.1371/journal.pone.0038216

Amin N et al, Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry 2012 Nov;17(11):1116-29. PMID: 21876539

Billings LK et al, Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes. 2012 Aug;61(8):2176-86. Epub 2012 Jun 14.

Boraska V et al, Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):803-11. PMID: 22911880; PMCID: PMC3494378.

Boraska V et al., Genome-wide Meta-analysis of Common Variant Differences between Men and Women. Hum Mol Genet. 2012 Jul 27. [Epub ahead of print]

Boraska V et al., Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One. 2012 Mar;7(3):e31369

Boutant M et al. (2012) Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity. PLoS ONE 7(5): e35810. doi:10.1371/journal.pone.0035810

Bradfield JP et al., A genome-wide association meta-analysis reveals new childhood obesity loci. Nature Genetics 2012; 44, 526-531. doi:10.1038/ng.2247 [Epub 08 April 2012]

Budin-Ljøsne I. A review of ethical frameworks for the disclosure of individual research results in population-based genetic and genomic research. Research Ethics. March 2012 8: 25-42, doi:10.1177/1747016111435576

Budin-Ljøsne I, Harris JR, Kaye J, Knoppers BM, Tassé AM, Bravo E, Cambon-Thomsen E, Eriksson M, Ohm Kyvik K, Litton J-E, Perola M and Rial-Sebbag E. ELSI challenges and strategies of national biobank infrastructures. Norsk Epidemiologi 2012; 21 (2): 155-160.

Cecelja M, Jiang B, Spector TD, Chowienczyk P. Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study. J Am Coll Cardiol. 2012 Jan 31;59(5):475-83. PubMed PMID: 22281250.

Chasman DI et al, Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012 Dec 15;21(24):5329-43. doi: 10.1093/hmg/dds369. Epub 2012 Sep 8.

Chew S et al, Copy number variation of the APC gene is associated with regulation of bone mineral density. Bone 2012 Nov;51(5):939-43. PMID: 22884971.

Clark C et al, A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(¨) for methylome profiling. PLoS One. 2012;7(11):e50233.Epub 2012 Nov 29.

Coviello AD et al, A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet 2012 Jul;8(7):e1002805. PMID: 22829776; PMCID: PMC3400553.

Dastani Z et al., Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45, 891 Individuals. PLoS Genet. 2012 Mar;8(3):e1002607. Epub 2012 Mar 29.

Davies RW et al., A genome wide association association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet. 2012 Apr 1;5(2):217-25. Epub 2012 Feb 7.

Dimas AS et al, Sex-biased genetic effects on gene regulation in humans. Genome Res. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 22960374.

Docampo E et al, Association of Neurexin 3 polymorphisms with smoking behavior. Genes Brain Behav. 2012 Aug;11(6):704-11.Epub 2012 Jul 17.

Ekelund M et al, Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus. Diab Res Clin Practice 97;394-98,2012.doi: 10.1016/j.diabres.2012.04.020. Epub 2012 May 14.

Ellinghaus E et al, Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. Invest Dermatol. 2012 Apr;132(4):1133-40. doi: 10.1038/jid.2011.415. Epub 2011 Dec 15.

Fagerholm E et al, FinnDiane Study Group. SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes. Diabetologia 2012 Sep;55(9):2386-93. doi: 10.1007/s00125-012-2587-0

Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome.Mol Cell Endocrinol. 2012 Sep 3. pii: S0303-7207(12)00413-3

Fall T et al, The role of obesity-related genetic loci in insulin sensitivity. Diabetic Medicine 2012 Jul;29(7) e62-e66(Epub : June 19 2012)

Fonseca NA, Rung J, Brazma A, Marioni JC. Tools for mapping high-throughput sequencing data. Bioinformatics. 2012 Dec 15;28(24):3169-77. Epub 2012 Oct 11.

Froguel P et al., A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels. PLoS One 2012;7(3):e32327. Epub 2012 Mar 5. (IF 4.411)

Gaál EI et al., Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure. PLoS Genet. 2012 Mar;8(3):e1002563.

Gervin K et al, DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. PLoS Genet. 2012 Jan;8(1):e1002454. doi: 10.1371/journal.pgen.1002454. Epub 2012 Jan 19.

Goek ON et al, Serum metabolite concentrations and decreased GFR in the general population. Am J Kidney Dis. 2012 Aug;60(2):197-206. doi: 10.1053/j.ajkd.2012.01.014. Epub 2012 Mar 30

Gostev M, Faulconbridge A, Brandizi M, Fernandez-Banet J, Sarkans U, Brazma A, Parkinson H. The BioSample Database (BioSD) at the European Bioinformatics Institute. Nucleic Acids Res. 2012 Jan;40(Database issue):D64-70. Epub 2011 Nov 16

Grundberg E et al, Mapping cis- and trans-regulatory effects across multiple tissues in twins. NatGenet. 2012 Sep 2;44(10):1084-1089. doi: 10.1038/ng.2394. Epub 2012 Sep 2. PubMed PMID: 22941192.

Hancock DB et al., Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012 Dec;8(12):e1003098. doi: 10.1371/journal.pgen.1003098. Epub 2012 Dec 20.

Harris JR, Burton P, Knoppers BM, Lindpaintner K and al. Towards a roadmap in global biobanking for health. European Journal of Human Genetics. Eur J Hum Genet. 2012 Jun 20. doi: 10.1038/ejhg.2012.96. [Epub ahead of print]

Harris JR, Haugan A, Budin-Lj¿sne I. Biobanking: from vision to reality. Norsk Epidemiologi 2012; 21 (2): 127-133

Hartz SM et al., Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry. 2012 Aug;69(8):854-60. doi: 10.1001/archgenpsychiatry.2012.124.

Helgadottir A et al., Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol. 2012 Aug 21;60(8):722-9. doi: 10.1016/j.jacc.2012.01.078.

Hoggart CJ, O'Reilly PF, Kaakinen M, Zhang W, Chambers JC, Kooner JS, Coin LJ, Järvelin M-R. Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism data. Genetics Feb, 2012;190(2):669-77. Epub 2011 Nov 17.

Huang J et al, Genome-wide association study for circulating levels of plasminogen activator inhibitor-1 (PAI-1) provides novel insights into the regulation of PAI-1. Blood 2012 Dec 6;120(24):4873-81. PMID: 22990020.

Hughes MF, Saarela O, Stritzke J, Kee F, Silander K, et al. (2012) Genetic Markers Enhance Coronary Risk Prediction in Men: The MORGAM Prospective Cohorts. PLoS ONE 7(7): e40922. doi:10.1371/journal.pone.0040922

Ikram MA et al. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 Apr 15;44(5):539-44. doi: 10.1038/ng.2245. [Epub ahead of print]

Kaakinen M et al, Associations between Variation in CHRNA5-CHRNA3-CHRNB4, Body Mass Index and Blood Pressure in the Northern Finland Birth Cohort 1966. PLoS One. 2012;7(9):e46557. doi: 10.1371/journal.pone.0046557. Epub 2012 Sep 27.

Kantomaa MT et al, Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1917-22. doi: 10.1073/pnas.1214574110. Epub 2012 Dec 31

Kettunen J, et al.,. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012 Jan 29;44(3):269-76. doi: 10.1038/ng.1073.

Kristiansson K et al., Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits. Circ Cardiovasc Genet. 2012; 5: 242-249

Köttgen A et al, Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2012 Dec 23. [Epub ahead of print] PMID: 23263486.

Liu F, van der Lijn F, Schurmann C, Zhu G, Chakravarty MM, et al. (2012) A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLoS Genet 8(9): e1002932. doi:10.1371/journal.pgen.1002932

Lu X, et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet. 2012 Jul 1;44(8):890-4 Luciano M et al, Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(2): 192-200 (2012)

Ivliev AE, ’t Hoen PA, van Roon WM, Peters DJ, Sergeeva MG. Exploring the Transcriptome of Ciliated Cells Using In Silico Dissection of Human Tissues. PLoS One. 2012;7(4):e35618. Epub 2012 Apr 25.

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. Collaborators: Ripke S et al, A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, Apr 3 [Epub ahead of print]"

Malley JD, Kruppa J, Dasgupta A, Malley KG, Ziegler A, Probability Machines: Consistent Probability Estimation Using Nonparametric Learning Machines, Methods Inf Med. 2012 January 10; 51(1): 74-81. Published online 2011 September 14.

Mangino M et al, Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet 2012 Dec 15;21(24):5385-94. PMID: 23001564; PMCID: PMC3510758.

Manning AK et al., Discovery of genetic variants implicated in insulin resistance through novel application of a genome-wide approach that accounts for body mass index and SNP by body mass index interaction on fasting glycemic traits. Nat Genet. 2012 May 13;44(6):659-69. doi: 10.1038/ng.2274.

Mastrokolias A, den Dunnen JT, van Ommen GB, 't Hoen PA, van Roon-Mom WM. Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA. BMC Genomics. 2012 Jan 18;13:28.

Middelberg et al., Loci affecting gamma-glutamyl transferase in adults and adolescents show age x snp interaction and cardiometabolic disease associations, Human Molecular Genetics, Jan 15;21(2):446-55.2012 [Epub 2011 Oct 18. ]

Moayyeri A, Hammond CJ, Valdes AM, Spector TD. Cohort Profile: TwinsUK and Healthy Ageing Twin Study. Int J Epidemiol. 2012 Jan 9. [Epub ahead of print] PubMed PMID: 22253318

Morris AP et al, Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012 Sep;44(9):981-90. doi: 10.1038/ng.2383. Epub 2012 Aug 12.

Murtagh, MJ et al, Navigating the perfect [data] storm. Norsk Epidemiologi 2012; 21(2), 203-209.

Mustelin L et al, Genetic influences on physical activity in young adults: a twin study. Med Sci Sports Exerc. 2012 Jul;44(7):1293-301. doi: 10.1249/MSS.0b013e3182479747.

Morales E, Bustamante M, Vilahur N, Escaramis G, Montfort M, de Cid R, Garcia-Esteban R, Torrent M, Estivill X, Grimalt JO, Sunyer J. DNA Hypomethylation at ALOX12 is Associated with Persistent Wheezing in Childhood. Am J Respir Crit Care Med. 2012 Feb 9. [Epub ahead of print] PMID:22323304

O'Reilly PF, Hoggart CJ, Pomyen Y, Calboli FC, Elliott P, Jarvelin MR, Coin LJ. MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS. PLoS ONE 2012; 7(5): e34861. doi:10.1371/journal.pone.0034861 Epud 2012 May2

Pattaro C et al., Genome-wide association and functional follow-up reveals new Loci for kidney function. PLoS Genet. 2012 Mar;8(3):e1002584. Epub 2012 Mar 29.

Petersen AK et al., Genetic associations with lipoprotein subfractions provide information on their biological nature .Hum Mol Genet. 2012 Mar 15;21(6):1433-43. Epub 2011 Dec 8.

Perry, JR et al. Stratifying type 2 Diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 2012 May;8(5):e1002741. Epub 2012 May 31.

Peyrot WJ et al, Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. Journal of Affective Disorders - Sep 26. doi: 10.1016/j.jad.2012.08.044 (2012)

Ramasamy A et al, Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One. 2012;7(9):e44008. PMID: 23028483; PMCID: PMC3461045.

Rhodes B, Fürnrohr BG, Roberts AL, Tzircotis G, Schett G, Spector TD, Vyse TJ. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. Ann Rheum Dis. 2012 Aug 8. [Epub ahead of print]

Sandholm N et al, New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 2012 Sep;8(9):e1002921. PMID: 23028342; PMCID: PMC3447939.doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20.

Scott RA et al, Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385. Epub 2012 Aug 12.

Service SK et al, A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Transl Psychiatry 2012 May 15;2:e116. PMID: 22832960; PMCID: PMC3365256.

Stein JL et al, Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012; 44(5): 552-561

Stolk L et al., Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012 Jan 9;44(3):260-8.

Stoltenberg C et al, From Biobanks for health to Biobank Norway. Norsk Epidemiologi 2012; 21 (2): 127-132

Surakka I et al, A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol.Twin Res Hum Genet. 2012 Oct 3:1-9. [Epub ahead of print]

Taal HR et al., Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 Apr 15;44(5):532-8. doi: 10.1038/ng.2238.[Epub ahead of print]

Terracciano A et al, Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. Translational Psychiatry 18(1):e49 (2012)

Thanabalasingham G et al, Mutations in HNF1A result in marked alterations of plasma glycan profile. Diabetes. 2012 Dec 28. [Epub ahead of print] doi: 10.2337/db12-0880

The CARDIoGRAMplusC4D Consortium, Deloukas P et al., Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2012 Dec 2. doi: 10.1038/ng.2480. [Epub ahead of print]

Traylor M et al, Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012 Nov;11(11):951-62. PMID: 23041239; PMCID: PMC3490334.

Tsoi LC et al, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467. Epub 2012 Nov 11.

Tyrrell J et al, Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet. 2012 Dec 15;21(24):5344-58. doi: 10.1093/hmg/dds372. Epub 2012 Sep 5.

van der Harst P et al, 75 genetic loci influencing the human red blood cell. Nature 492;369-75,2012). doi: 10.1038/nature11677. Epub 2012 Dec 5.

van Koolwijk LME et al, Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma. PLoS Genet 2012; 8(5): e1002611. doi:10.1371/journal.pgen.1002611

Verhoeven VJ et al, Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Hum Genet. 2012 Sep;131(9):1467-80. doi: 10.1007/s00439-012-1176-0. Epub 2012 Jun 5.

Verweij KJ et al, Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.Evolution. 2012 Oct;66(10):3238-51. doi: 10.1111/j.1558-5646.2012.01679.x. Epub 2012 May 21.

Vishram JKK et al, on behalf of the MORGAM Project. Impact of age on the importance of systolic and diastolic blood pressure for stroke risk: The MOnica, Risk, Genetics Archiving and Monograph (MORGAM) Project. Hypertension;60:1117-1123,2012..

Würtz P et al, Metabolic Signatures of Insulin Resistance in 7,098 Young Adults. Diabetes. 2012 Jun;61(6):1372-80. doi: 10.2337/db11-1355. Epub 2012 Apr 17.

Yang J et al, FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401. Epub 2012 Sep 16. [Epub ahead of print]

 

2011

Ahluwalia, TS, Lindholm, E, Groop, LC. Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes. Diabetologia 2011;54(9), 2295-302

Almgren P, Lehtovirta M, Isomaa B, Sarelin L, Taskinen MR, Lyssenko V, Tuomi T, Groop L, for the Botnia Study Group. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 2011; 54(11), 2811-19

Amin N et al., Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2011 Aug 30. doi: 10.1038/mp.2011.101.

Anvar S. Yahya, Tucker Allan, Vinciotti Veronica, Venema Andrea, van Ommen Gertjan B., van der Maarel, Silvère M. Raz Vered,’t Hoen Peter A.C., Interspecies translation of disease networks increases robustness and predictive accuracy. PLoS Computational Biology 7: e1002258 (2011)

Barker A et al., Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011 Jun;60(6):1805-12. Epub 2011 Apr 22.

Berglund E, Kiialainen A, Syvänen A-C. Next Generation Sequencing Technologies and Applications for Human Genetic History and Forensics. Investigative Genetics 2:23, 2011, PMC3267688

Bodenant M, Kuulasmaa K, Wagner A, Kee F, Palmieri L, Ferrario MM, Montaye M, Amouyel P, Dallongeville J; for the MORGAM Project. Measures of abdominal adiposity and the risk of stroke: The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study. Stroke 2011;42:2872-2877.

Budin-Ljosne I, Tasse AM, Knoppers BM, Harris JR.Bridging consent: From toll bridges to lift bridges? BMC Med Genomics. 2011 Oct 4;4(1):69. (ENGAGE led)]

Chambers JC et al., Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 43(11):1131-8, 2011

Day-Williams AG et al., A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. Epub 2011 Aug

Dehghan A et al., Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011 Feb 22; 123(7)731-8

Demirkan et al.. Genetic architecture of circulating lipid levels. European Journal of Human Genetics 2011 July; 19, 813-819. doi:10.1038/ejhg.2011.21 (ENGAGE led)

Desrivières S, Lourdusamy A, Müller C, Ducci F, Wong CP, Kaakinen M, Pouta A, Hartikainen AL, Isohanni M, Charoen P, Peltonen L, Freimer N, Elliott P, Jarvelin MR, Schumann G., Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.Addict Biol. 2011 Jul;16(3):510-3. Epub 2010 Aug 23

Erdmann J et al., Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J 2011; 32, 158-168 [Epub 2010 Nov 18]

Ferreira MA et al., Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet. 78(9795): 1006-14, 2011

Fortier I, Doiron D, Little J, Ferretti V, L’heureux F, Stolk RP, Knoppers BM, Hudson TJ, Burton PR; on behalf of the International Harmonization Initiative. Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J epidemiol. 2011 Jul 30

Gervin K, Hammerø M, Akselsen HE, Moe R, Nygård H, Brandt I, Gjessing HK, Harris JR, Undlien DE, Lyle R. Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Res. 2011 Nov;21(11):1813-21. Epub 2011 Sep 26.

Gieger et al. New gene functions in megakaryopoiesis and platelet formation.. Nature. 2011 Nov 30. doi: 10.1038/nature10659. [Epub ahead of print]

Gostev M et al., SAIL—a software system for sample and phenotype availability across biobanks and cohorts. Bioinformatics. 2011 Feb15;27(4):589-91. doi: 10.1093/bioinformatics/btq693 (ENGAGE led)

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Knoppers et al.. Towards a data sharing Code of Conduct for international genomic research. Genome Medicine 2011, 3:46 doi:10.1186/gm262 (ENGAGE led)

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Maugeri N, Powell J, 't Hoen PA, de Geus EJ, Willemsen G, Kattenberg M, Henders AK, Wallace L, Penninx B, Hottenga JJ, Medland SE, Saviouk V, Martin NG, Visscher PM, van Ommen GJ, Frazer IH, Boomsma DI, Montgomery GW, Ferreira MA. LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Human Mutation, 32(8):873-6, 2011

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Soler Artigas M, et al., Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nat Genet. 2011 Sep 25;43(11):1082-90. doi: 10.1038/ng.941.

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Tassé AM. The Return of Results of Deceased Research Participants. Journal of Law, Medicine and Ethics 2011(39):4, 621-630.

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Zhai G. et al.,. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14.

 

2010

Blankenberg et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation. 2010 Jun 8;121(22):2388-97. Epub 2010 May 24.

Chambers et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):373-5. Epub 2010 Apr 11.

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Pillas et al. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics 2010;6:e1000856.

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Saccone et al.. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. 2010 Aug 5;6(8). pii: e1001053.

Solveig Gretarsdottir, et al., Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692-7. Epub 2010 Jul 11.

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Voight et al.. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42: 579–589

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2009

Aulchenko, Ripatti et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics 41, 47 - 55 (2009) Published online: 7 December 2008 (ENGAGE led publication)

Bartha Maria Knoppers. Genomics and policymaking: from static models to complex systems? Human Genetics 2009 May;125(4):375-9. Epub 2009 Feb 28

Chambers et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics 41(11), 1161-2 (2009). Published online: 11 October 2009

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Iris M. Heid et al., Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Plos Gen 2009;5:e1000694

Jonsson et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Oct;58(10):2409-13. Epub 2009 Jul 7.

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Kolz et al. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.

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Richards et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.

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Soranzo et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics 41(11), 1182- 90 (2009). Published online: 11 October 2009

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2008

Saarela O et al. Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives. Stat Med. 2008 Dec 10;27(28):5991-6008.

Grisoni M-L et al. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. European Journal of Human Genetics. 2008 Dec;16(12):1512-20. Epub 2008 Jul 16.