PRESS AND PUBLICATIONS

All the publications below acknowledge ENGAGE funding
European Community's Seventh Framework Programme (FP7/2007-2013); Grant Agreement HEALTH-F4-2007- 201413

2011

Gervin K, Hammerø M, Akselsen HE, Moe R, Nygård H, Brandt I, Gjessing HK, Harris JR, Undlien DE, Lyle R. Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Res. 2011 Nov;21(11):1813-21. Epub 2011 Sep 26.

Budin-Ljosne I, Tasse AM, Knoppers BM, Harris JR.Bridging consent: From toll bridges to lift bridges? BMC Med Genomics. 2011 Oct 4;4(1):69. [Epub ahead of print]

Surakka, Isaacs et al.. A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. PLoS Genetics 2011 Oct;7(10):e1002333 (Epub 2011 Oct 20) doi: 10.1371/journal.pgen.1002333 (ENGAGE led)

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret et al., Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature Volume: 478, Pages: 103–109 Date published: (06 October 2011) DOI: doi:10.1038/nature10405

Wain et al., Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics Volume: 43, Pages: 1005–1011 Year published: (2011) DOI: doi:10.1038/ng.922

Suhre et al., Human metabolic individuality in biomedical and pharmaceutical research. Nature Volume: 477, Pages: 54–60 Date published: (01 September 2011) DOI: doi:10.1038/nature10354

Knoppers et al.. Towards a data sharing Code of Conduct for international genomic research. Genome Medicine 2011, 3:46 doi:10.1186/gm262 (ENGAGE led)

Demirkan et al.. Genetic architecture of circulating lipid levels. European Journal of Human Genetics 2011 July; 19, 813-819. doi:10.1038/ejhg.2011.21 (ENGAGE led)

Obeidat M et al., A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS One. 2011;6(5):e19382. Epub 2011 May 20

Small KS et al., Identification of an imprinted master trans-regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet. 2011 Jun;43(6):561-4. Epub 2011 May 15.

Schumann G et al.. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. PNAS. 2011 April; 108(17):7119-24. doi: 10.1073/pnas.1017288108

Zhai G. et al.,. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14.

Vangjeli C. et al., A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project., J Renin Angiotensin Aldosterone Syst. 2011 Apr 13

Barker A et al., Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011 Jun;60(6):1805-12. Epub 2011 Apr 22.

Mustelin L. et al., Genetic influences on physical activity in young adults. A twin study. J Appl Physiol. 2011 Mar;110(3):681-6. Epub 2010 Dec 30.

Dehghan A et al., Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011 Feb 22; 123(7)731-8

Sovio U et al., Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet. 2011 Feb;7(2):e1001307. Epub 2011 Feb 17

Gostev M et al., SAIL—a software system for sample and phenotype availability across biobanks and cohorts. Bioinformatics. 2011 Feb15;27(4):589-91. doi: 10.1093/bioinformatics/btq693 (ENGAGE led)

Jelier R et al., Literature-aided interpretation of gene expression data with the weighted global test. Briefings in Bioinformatics. 2011 Feb9 [Epub ahead of print].; doi: 10.1093/bib/bbq082

2010

Heid IM et al.. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Oct 10. [Epub ahead of print]

Speliotes EK et al.. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Oct 10. [Epub ahead of print]

Lango Allen H, et al., Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Sep 29. [Epub ahead of print]

Waterworth et al., Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2010 Sep 23. [Epub ahead of print]

Soranzo N, et al., Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways.Diabetes. 2010 Sep 21. [Epub ahead of print]

Elks CE et al., Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 2010 Dec;42(12):1077-85.

Owen KR, et al..Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care. 2010 Sep;33(9):1919-24. Epub 2010 Aug 19.

Solveig Gretarsdottir, et al., Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692-7. Epub 2010 Jul 11.

Saccone et al.. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. 2010 Aug 5;6(8). pii: e1001053.

Teslovich et al.. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 August; 466(7307):707-13

Voight et al.. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42: 579–589

Wang et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jun 9. [Epub ahead of print]

Naukkarinen et al. Use of genome-wide expression studies to mine the "gray zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet. 2010 Jun 3;6(6):e1000976. (ENGAGE led publication)

Blankenberg et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation. 2010 Jun 8;121(22):2388-97. Epub 2010 May 24.

Widén et al. Distinct variants at LIN28B influence growth in height from birth to adulthood. Am J Hum Genet. 2010 May 14;86(5):773-82. Epub 2010 Apr 15.

Walters et al. A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome 16p11. Nature 2010;463:671-675. PMID: 20130649

Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior and the risk of lung cancer. Nat Genet 2010;42:448-453.

Pillas et al. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics 2010;6:e1000856.

Freathy et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010 May;42(5):430-5. Epub 2010 Apr 6.

Chambers et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):373-5. Epub 2010 Apr 11.

Tassé AM, Budin-Ljøsne I, Knoppers BM, Harris JR. Retrospective access to data: the ENGAGE consent experience. Eur J Hum Genet. 2010 Mar 24. [Epub ahead of print]

Ingelsson et al. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. Diabetes (2010) 59; 1266-75 Feb 25. [Epub ahead of print]

Milani et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood. 2010 Feb 11;115(6):1214-25. Epub 2009 Nov 25.

Saxena et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010 Feb;42(2):142-8. Epub 2010 Jan 17.

Codd et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010 Mar;42(3):197-9. Epub 2010 Feb 7.

Dupuis et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Jan 17.

Illig et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41. Epub 2009 Dec 27.

Repapi et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010 Jan;42(1):36-44. Epub 2009 Dec 13. PubMed PMID: 20010834.

2009

Richards et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.

Menezes et al. Integrated analysis of DNA copy number and gene expression microarray data using gene sets. BMC Bioinformatics 10:203 (2009)

Eleftherohorinou et al. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One. Nov 30;4(11) (2009).

Soranzo et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics 41(11), 1182- 90 (2009). Published online: 11 October 2009

Chambers et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics 41(11), 1161-2 (2009). Published online: 11 October 2009

Krestyaninova et al. A System for Information Management in BioMedical Studies--SIMBioMS. Bioinformatics. 2009 Oct 15;25(20):2768-9. Epub 2009 Jul 24.

Jonsson et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Oct;58(10):2409-13. Epub 2009 Jul 7.

Kolz et al. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.

Grisoni et al. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 2009 May 27;10:44.

Saarela O, Kulathinal S, Karvanen J. Joint analysis of prevalence and incidence data using conditional likelihood. Biostatistics. 2009 Jul;10(3):575-87. Epub 2009 May 20.

Newton-Cheh et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41, 666 - 676 (2009). 2009 May 10. [Epub ahead of print]

Iris M. Heid et al., Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Plos Gen 2009;5:e1000694

Karvanen et al. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009;33:237-246.

Mari Nelis, Tõnu Esko et al. Genetic Structure of Europeans: a view from the North-East. PLoS ONE 4(5): e5472

Sovio U et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009 Mar;5(3):e1000409. Epub 2009 Mar 6.

Bartha Maria Knoppers. Genomics and policymaking: from static models to complex systems? Human Genetics 2009 May;125(4):375-9. Epub 2009 Feb 28

Pulizzi et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia. 2009 May;52(5):825-9. Epub 2009 Feb 19.

Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009 May;29(5):774-80. Epub 2009 Jan 22.

Erdmann et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics. 2009 Mar;41(3):280-2. Epub 2009 Feb 8.

Valeriya et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature Genetics 41, 82 - 88 (2009) Published online: 7 December 2008

Inga Prokopenko et al. Variants in MTNR1B fasting glucose levels. Nature Genetics 41, 77 - 81 (2009) Published online: 7 December 2008 | doi:10.1038/ng.290 (ENGAGE led publication)

Aulchenko, Ripatti et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics 41, 47 - 55 (2009) Published online: 7 December 2008 (ENGAGE led publication)

Sabatti et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics 41, 35 - 46 (2009). Published online: 7 December 2008

Willer et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41:25-34 (2009)

Gudmar Thorleifsson et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 41, 18 - 24 (2009). Published online: 14 December 2008

2008

Saarela O et al. Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives. Stat Med. 2008 Dec 10;27(28):5991-6008.

Grisoni M-L et al. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. European Journal of Human Genetics. 2008 Dec;16(12):1512-20. Epub 2008 Jul 16.