PRESS AND PUBLICATIONS
All the publications below acknowledge ENGAGE funding
European Community's Seventh Framework Programme (FP7/2007-2013); Grant Agreement HEALTH-F4-2007- 201413
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'European Netwok for Genetic and Genomic Epidemiology-ENGAGE video
2012
The CARDIoGRAMplusC4D Consortium, Deloukas P et al., Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2012 Dec 2. doi: 10.1038/ng.2480. [Epub ahead of print]
Boraska V et al., Genome-wide Meta-analysis of Common Variant Differences between Men and Women. Hum Mol Genet. 2012 Jul 27. [Epub ahead of print]
Boraska V et al., Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One. 2012 Mar;7(3):e31369
Bradfield JP et al., A genome-wide association meta-analysis reveals new childhood obesity loci. Nature Genetics 2012; 44, 526-531. doi:10.1038/ng.2247 [Epub 08 April 2012]
Budin-Ljøsne I. A review of ethical frameworks for the disclosure of individual research results in population-based genetic and genomic research. Research Ethics. March 2012 8: 25-42, doi:10.1177/1747016111435576
Budin-Ljøsne I, Harris JR, Kaye J, Knoppers BM, Tassé AM, Bravo E, Cambon-Thomsen E, Eriksson M, Ohm Kyvik K, Litton J-E, Perola M and Rial-Sebbag E. ELSI challenges and strategies of national biobank infrastructures. Norsk Epidemiologi 2012; 21 (2): 155-160.
Cecelja M, Jiang B, Spector TD, Chowienczyk P. Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study. J Am Coll Cardiol. 2012 Jan 31;59(5):475-83. PubMed PMID: 22281250.
Dastani Z et al., Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45, 891 Individuals. PLoS Genet. 2012 Mar;8(3):e1002607. Epub 2012 Mar 29.
Davies RW et al., A genome wide association association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet. 2012 Apr 1;5(2):217-25. Epub 2012 Feb 7.
Froguel P et al., A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels. PLoS One 2012;7(3):e32327. Epub 2012 Mar 5. (IF 4.411)
Gaál EI et al., Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure. PLoS Genet. 2012 Mar;8(3):e1002563.
Gostev M, Faulconbridge A, Brandizi M, Fernandez-Banet J, Sarkans U, Brazma A, Parkinson H. The BioSample Database (BioSD) at the European Bioinformatics Institute. Nucleic Acids Res. 2012 Jan;40(Database issue):D64-70. Epub 2011 Nov 16
Harris JR, Haugan A, Budin-Ljøsne I. Biobanking: from vision to reality. Norsk Epidemiologi 2012; 21 (2): 127-133
Harris JR, Burton P, Knoppers BM, Lindpaintner K and al. Towards a roadmap in global biobanking for health. European Journal of Human Genetics. Eur J Hum Genet. 2012 Jun 20. doi: 10.1038/ejhg.2012.96. [Epub ahead of print]
Hoggart CJ, O'Reilly PF, Kaakinen M, Zhang W, Chambers JC, Kooner JS, Coin LJ, Järvelin M-R. Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism data. Genetics Feb, 2012;190(2):669-77. Epub 2011 Nov 17.
Ikram MA et al. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 Apr 15;44(5):539-44. doi: 10.1038/ng.2245. [Epub ahead of print]
Kettunen J, et al.,. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012 Jan 29;44(3):269-76. doi: 10.1038/ng.1073.
Kristiansson K et al., Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits. Circ Cardiovasc Genet. 2012; 5: 242-249
Ivliev AE, ’t Hoen PA, van Roon WM, Peters DJ, Sergeeva MG. Exploring the Transcriptome of Ciliated Cells Using In Silico Dissection of Human Tissues. PLoS One. 2012;7(4):e35618. Epub 2012 Apr 25.
Manning AK et al., Discovery of genetic variants implicated in insulin resistance through novel application of a genome-wide approach that accounts for body mass index and SNP by body mass index interaction on fasting glycemic traits. Nat Genet. 2012 May 13;44(6):659-69. doi: 10.1038/ng.2274.
Mastrokolias A, den Dunnen JT, van Ommen GB, 't Hoen PA, van Roon-Mom WM. Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA. BMC Genomics. 2012 Jan 18;13:28.
Middelberg et al., Loci affecting gamma-glutamyl transferase in adults and adolescents show age x snp interaction and cardiometabolic disease associations, Human Molecular Genetics, Jan 15;21(2):446-55.2012 [Epub 2011 Oct 18. ]
Moayyeri A, Hammond CJ, Valdes AM, Spector TD. Cohort Profile: TwinsUK and Healthy Ageing Twin Study. Int J Epidemiol. 2012 Jan 9. [Epub ahead of print] PubMed PMID: 22253318
Morales E, Bustamante M, Vilahur N, Escaramis G, Montfort M, de Cid R, Garcia-Esteban R, Torrent M, Estivill X, Grimalt JO, Sunyer J. DNA Hypomethylation at ALOX12 is Associated with Persistent Wheezing in Childhood. Am J Respir Crit Care Med. 2012 Feb 9. [Epub ahead of print] PMID:22323304
O'Reilly PF, Hoggart CJ, Pomyen Y, Calboli FC, Elliott P, Jarvelin MR, Coin LJ. MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS. PLoS ONE 2012; 7(5): e34861. doi:10.1371/journal.pone.0034861 Epud 2012 May2
Pattaro C et al., Genome-wide association and functional follow-up reveals new Loci for kidney function. PLoS Genet. 2012 Mar;8(3):e1002584. Epub 2012 Mar 29.
Petersen AK et al., Genetic associations with lipoprotein subfractions provide information on their biological nature .Hum Mol Genet. 2012 Mar 15;21(6):1433-43. Epub 2011 Dec 8.
Perry, JR et al. Stratifying type 2 Diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 2012 May;8(5):e1002741. Epub 2012 May 31.
Rhodes B, Fürnrohr BG, Roberts AL, Tzircotis G, Schett G, Spector TD, Vyse TJ. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. Ann Rheum Dis. 2012 Aug 8. [Epub ahead of print]
Stolk L et al., Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012 Jan 9;44(3):260-8.
Taal HR et al., Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 Apr 15;44(5):532-8. doi: 10.1038/ng.2238.[Epub ahead of print]
2011
Ahluwalia, TS, Lindholm, E, Groop, LC. Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes. Diabetologia 2011;54(9), 2295-302
Almgren P, Lehtovirta M, Isomaa B, Sarelin L, Taskinen MR, Lyssenko V, Tuomi T, Groop L, for the Botnia Study Group. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 2011; 54(11), 2811-19
Amin N et al., Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2011 Aug 30. doi: 10.1038/mp.2011.101.
Anvar S. Yahya, Tucker Allan, Vinciotti Veronica, Venema Andrea, van Ommen Gertjan B., van der Maarel, Silvère M. Raz Vered,’t Hoen Peter A.C., Interspecies translation of disease networks increases robustness and predictive accuracy. PLoS Computational Biology 7: e1002258 (2011)
Barker A et al., Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011 Jun;60(6):1805-12. Epub 2011 Apr 22.
Berglund E, Kiialainen A, Syvänen A-C. Next Generation Sequencing Technologies and Applications for Human Genetic History and Forensics. Investigative Genetics 2:23, 2011, PMC3267688
Bodenant M, Kuulasmaa K, Wagner A, Kee F, Palmieri L, Ferrario MM, Montaye M, Amouyel P, Dallongeville J; for the MORGAM Project. Measures of abdominal adiposity and the risk of stroke: The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study. Stroke 2011;42:2872-2877.
Budin-Ljosne I, Tasse AM, Knoppers BM, Harris JR.Bridging consent: From toll bridges to lift bridges? BMC Med Genomics. 2011 Oct 4;4(1):69. (ENGAGE led)]
Chambers JC et al., Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 43(11):1131-8, 2011
Day-Williams AG et al., A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. Epub 2011 Aug
Dehghan A et al., Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011 Feb 22; 123(7)731-8
Demirkan et al.. Genetic architecture of circulating lipid levels. European Journal of Human Genetics 2011 July; 19, 813-819. doi:10.1038/ejhg.2011.21 (ENGAGE led)
Desrivières S, Lourdusamy A, Müller C, Ducci F, Wong CP, Kaakinen M, Pouta A, Hartikainen AL, Isohanni M, Charoen P, Peltonen L, Freimer N, Elliott P, Jarvelin MR, Schumann G., Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.Addict Biol. 2011 Jul;16(3):510-3. Epub 2010 Aug 23
Erdmann J et al., Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J 2011; 32, 158-168 [Epub 2010 Nov 18]
Ferreira MA et al., Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet. 78(9795): 1006-14, 2011
Fortier I, Doiron D, Little J, Ferretti V, L’heureux F, Stolk RP, Knoppers BM, Hudson TJ, Burton PR; on behalf of the International Harmonization Initiative. Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J epidemiol. 2011 Jul 30
Gervin K, Hammerø M, Akselsen HE, Moe R, Nygård H, Brandt I, Gjessing HK, Harris JR, Undlien DE, Lyle R. Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Res. 2011 Nov;21(11):1813-21. Epub 2011 Sep 26.
Gieger et al. New gene functions in megakaryopoiesis and platelet formation.. Nature. 2011 Nov 30. doi: 10.1038/nature10659. [Epub ahead of print]
Gostev M et al., SAIL—a software system for sample and phenotype availability across biobanks and cohorts. Bioinformatics. 2011 Feb15;27(4):589-91. doi: 10.1093/bioinformatics/btq693 (ENGAGE led)
Hertel JK, Johansson S, Sonestedt E, Jonsson A, Lie RT, Platou CG, Nilsson PM, Rukh G, Midthjell K, Hveem K, Melander O, Groop L, Lyssenko V, Molven A, Orho-Melander M, Njølstad PR. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes. 2011 May;60(5):1637-44. Epub 2011 Mar 11.
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret et al., Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature Volume: 478, Pages: 103–109 Date published: (06 October 2011) DOI: doi:10.1038/nature10405
Jacquemont S et al., Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 2011 Aug 31[Epub ahead of print] PMID: 21881559
Jelier R et al., Literature-aided interpretation of gene expression data with the weighted global test. Briefings in Bioinformatics. 2011 Feb9 [Epub ahead of print].; doi: 10.1093/bib/bbq082
Kiialainen A, Karlberg O, Ahlford A, Sigurdsson S, Lindblad-Toh K, Syvänen AC. Performance of microarray and liquid based capture methods for target enrichment for massively parallel sequencing and SNP discovery. PLoS One. 2011 Feb 9;6(2):e16486.
Kilpeläinen TO et al., Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Med. 2011 Nov;8(11):e1001116. Epub 2011 Nov 1.
Kilpeläinen TO et al., Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011 Jun 26;43(8):753-60. doi:10.1038/ng.866. PubMed PMID: 21706003
Knoppers BM, Harris JR, Burton PR, Murtagh M, Cox D, Deschenes M, Fortier I, Hudson TJ, Kaye J, Lindpainter k. From genomic databases to translation: a call to action. J Med Ethics. 2011 May 26. [Epub ahead of print] PMID:21617164 (ENGAGE led)
Knoppers et al.. Towards a data sharing Code of Conduct for international genomic research. Genome Medicine 2011, 3:46 doi:10.1186/gm262 (ENGAGE led)
Knoppers BM, Hudson TJ. The art and science of biobanking. Hum Genet. 2011 Sep; 130(3):329-32. Epub 2011 Jul 21.
Kraja AT et al.,A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium. Diabetes 2011;60:1329-1339
Kutalik Z et al., Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. Hum Mol Genet. 2011 Sep 15;20(18):3710-7. Epub 2011 Jun 10. PubMed PMID: 21665994; PubMed Central PMCID: PMC3159549.
Ligthart L et al., Meta-analysis of genome-wide association for migraine in six population-based European cohorts. Eur J Hum Genet. 2011 Aug;19(8):901-7. doi: 10.1038/ejhg.2011.48. Epub 2011 Mar 30.
Lyssenko V, Eliasson L, Kotova O et al. Pleiotropic effects of a variant in the GIPR gene on islet function and risk of type 2 diabetes. Diabetes 60;2424-33,2011 PMC3161325
Maugeri N, Powell J, 't Hoen PA, de Geus EJ, Willemsen G, Kattenberg M, Henders AK, Wallace L, Penninx B, Hottenga JJ, Medland SE, Saviouk V, Martin NG, Visscher PM, van Ommen GJ, Frazer IH, Boomsma DI, Montgomery GW, Ferreira MA. LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Human Mutation, 32(8):873-6, 2011
Min JL, Taylor JM, Richards JB, Watts T, Pettersson FH, Broxholme J, Ahmadi KR, Surdulescu GL, Lowy E, Gieger C, Newton-Cheh C, Perola M, Soranzo N, Surakka I, Lindgren CM, Ragoussis J, Morris AP, Cardon LR, Spector TD, Zondervan KT. The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits. PLoS One. 2011;6(7):e22070. Epub 2011 Jul 15.
Murtagh MJ, Demir I, Harris JR, Burton PR. Realizing the promise of population biobanks: a new model for translation. Hum Genet. 2011 Sep;130(3):333-45 PMID: 21706184
Mustelin L. et al., Genetic influences on physical activity in young adults. A twin study. J Appl Physiol. 2011 Mar;110(3):681-6. Epub 2010 Dec 30.
Nalls MA et al., Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011 Jun;7(6):e1002113. Epub 2011 Jun 30.
Obeidat M et al., A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS One. 2011;6(5):e19382. Epub 2011 May 20
Paternoster L, et al., the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Weidinger S. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2011 Dec 25;44(2):187-192.
Pietiläinen OP, Rehnström K, Jakkula E, Service SK, Congdon E, Tilgmann C, Hartikainen AL, Taanila A, Heikura U, Paunio T, Ripatti S, Jarvelin MR, Isohanni M, Sabatti C, Palotie A, Freimer NB, Peltonen L. Phenotype mining in CNV carriers from a population cohort. Hum Mol Genet. 2011 Jul 1;20(13):2686-95. Epub 2011 Apr 19
Schumann G et al.. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. PNAS. 2011 April; 108(17):7119-24. doi: 10.1073/pnas.1017288108
Small KS et al., Identification of an imprinted master trans-regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet. 2011 Jun;43(6):561-4. Epub 2011 May 15.
Smith NL, et al., Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011 May 3;123(17):1864-72. Epub 2011 Apr 18
Soler Artigas M, et al., Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nat Genet. 2011 Sep 25;43(11):1082-90. doi: 10.1038/ng.941.
Soler Artigas M et al.,SpiroMeta Consortium. Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function. Am J Respir Crit Care Med. 2011 Oct 1;184(7):786-95.
Sovio U et al., Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet. 2011 Feb;7(2):e1001307. Epub 2011 Feb 17
Strawbridge RJ*, Dupuis J*, Prokopenko I*, Barker A*, Ahlqvist E* et al., Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011:60:2624-2634. PMID: 21873549
Suhre et al., Human metabolic individuality in biomedical and pharmaceutical research. Nature Volume: 477, Pages: 54–60 Date published: (01 September 2011) DOI: doi:10.1038/nature10354
Surakka I, Isaacs A et al.. A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. PLoS Genetics 2011 Oct;7(10):e1002333 (Epub 2011 Oct 20) doi: 10.1371/journal.pgen.1002333 (ENGAGE led)
Tassé AM. The Return of Results of Deceased Research Participants. Journal of Law, Medicine and Ethics 2011(39):4, 621-630.
Tassé AM. Biobanking and Deceased Persons, Hum Genet 2011 (130) 415-423.
Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, Gasperikova D, Szopa M, Tjora E, James TJ, Kokjo P, Loiseleur F, Andersson E, Gaget S, Isomaa B, Nowak N, Raeder H, Stanik J, Njolstad PR, Malecki MT, Klimes I, Groop L, Pedersen O, Froguel P, McCarthy MI, Gloyn AL, Owen KR. A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia 2011 Aug 4 (Epub ahead of print) PMID:21814873
Vangjeli C. et al., A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project., J Renin Angiotensin Aldosterone Syst. 2011 Apr 13
Wain et al., Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics Volume: 43, Pages: 1005–1011 Year published: (2011) DOI: doi:10.1038/ng.922
Zhai G. et al.,. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14.
2010
Blankenberg et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation. 2010 Jun 8;121(22):2388-97. Epub 2010 May 24.
Chambers et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):373-5. Epub 2010 Apr 11.
Codd et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010 Mar;42(3):197-9. Epub 2010 Feb 7.
Dupuis et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Jan 17.
Elks CE et al., Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 2010 Dec;42(12):1077-85.
Freathy et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010 May;42(5):430-5. Epub 2010 Apr 6.
Heid IM et al.. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Oct 10. [Epub ahead of print]
Illig et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41. Epub 2009 Dec 27.
Ingelsson et al. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. Diabetes (2010) 59; 1266-75 Feb 25. [Epub ahead of print]
Lango Allen H, et al., Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Sep 29. [Epub ahead of print]
Milani et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood. 2010 Feb 11;115(6):1214-25. Epub 2009 Nov 25.
Naukkarinen et al. Use of genome-wide expression studies to mine the "gray zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet. 2010 Jun 3;6(6):e1000976. (ENGAGE led publication)
Owen KR, et al..Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care. 2010 Sep;33(9):1919-24. Epub 2010 Aug 19.
Pillas et al. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics 2010;6:e1000856.
Repapi et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010 Jan;42(1):36-44. Epub 2009 Dec 13. PubMed PMID: 20010834.
Saxena et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010 Feb;42(2):142-8. Epub 2010 Jan 17.
Saccone et al.. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. 2010 Aug 5;6(8). pii: e1001053.
Solveig Gretarsdottir, et al., Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692-7. Epub 2010 Jul 11.
Soranzo N, et al., Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways.Diabetes. 2010 Sep 21. [Epub ahead of print]
Speliotes EK et al.. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Oct 10. [Epub ahead of print]
Tassé AM, Budin-Ljøsne I, Knoppers BM, Harris JR. Retrospective access to data: the ENGAGE consent experience. Eur J Hum Genet. 2010 Mar 24. [Epub ahead of print]
Teslovich et al.. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 August; 466(7307):707-13
Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior and the risk of lung cancer. Nat Genet 2010;42:448-453.
Voight et al.. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42: 579–589
Wang et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jun 9. [Epub ahead of print]
Walters et al. A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome 16p11. Nature 2010;463:671-675. PMID: 20130649
Waterworth et al., Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2010 Sep 23. [Epub ahead of print]
Widén et al. Distinct variants at LIN28B influence growth in height from birth to adulthood. Am J Hum Genet. 2010 May 14;86(5):773-82. Epub 2010 Apr 15.
2009
Aulchenko, Ripatti et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics 41, 47 - 55 (2009) Published online: 7 December 2008 (ENGAGE led publication)
Bartha Maria Knoppers. Genomics and policymaking: from static models to complex systems? Human Genetics 2009 May;125(4):375-9. Epub 2009 Feb 28
Chambers et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics 41(11), 1161-2 (2009). Published online: 11 October 2009
Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009 May;29(5):774-80. Epub 2009 Jan 22.
Eleftherohorinou et al. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One. Nov 30;4(11) (2009).
Erdmann et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics. 2009 Mar;41(3):280-2. Epub 2009 Feb 8.
Grisoni et al. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 2009 May 27;10:44.
Inga Prokopenko et al. Variants in MTNR1B fasting glucose levels. Nature Genetics 41, 77 - 81 (2009) Published online: 7 December 2008 | doi:10.1038/ng.290 (ENGAGE led publication)
Iris M. Heid et al., Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Plos Gen 2009;5:e1000694
Jonsson et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Oct;58(10):2409-13. Epub 2009 Jul 7.
Karvanen et al. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009;33:237-246.
Kolz et al. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.
Krestyaninova et al. A System for Information Management in BioMedical Studies--SIMBioMS. Bioinformatics. 2009 Oct 15;25(20):2768-9. Epub 2009 Jul 24.
Menezes et al. Integrated analysis of DNA copy number and gene expression microarray data using gene sets. BMC Bioinformatics 10:203 (2009)
Newton-Cheh et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41, 666 - 676 (2009). 2009 May 10. [Epub ahead of print]
Nelis M, Esko T et al. Genetic Structure of Europeans: a view from the North-East. PLoS ONE 4(5): e5472
Pulizzi et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia. 2009 May;52(5):825-9. Epub 2009 Feb 19.
Richards et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.
Saarela O, Kulathinal S, Karvanen J. Joint analysis of prevalence and incidence data using conditional likelihood. Biostatistics. 2009 Jul;10(3):575-87. Epub 2009 May 20.
Sabatti et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics 41, 35 - 46 (2009). Published online: 7 December 2008
Soranzo et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics 41(11), 1182- 90 (2009). Published online: 11 October 2009
Sovio U et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009 Mar;5(3):e1000409. Epub 2009 Mar 6.
Thorleifsson G et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 41, 18 - 24 (2009). Published online: 14 December 2008
Valeriya et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature Genetics 41, 82 - 88 (2009) Published online: 7 December 2008
Willer et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41:25-34 (2009)
2008
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Grisoni M-L et al. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. European Journal of Human Genetics. 2008 Dec;16(12):1512-20. Epub 2008 Jul 16. |
