Epidemiology and Joint Effects (WP6)

WP6 focuses on understanding how these variants interact with each other and with pertinent environmental/lifestyle exposures at the population-level, and on obtaining more precise estimates of their individual and joint effects on disease progression and risk. We will make best use of data from isolates/large pedigrees, prospective cohorts and our unique twin resources to support studies of such joint effects. Such information is essential for efforts at clinical translation.